Relationship between Vitamin A and Bone Disease in Chronic Renal Failure
作者:
P.B. Rylance,
I.R.F. Brown,
DW. Howells,
J.A. Nisbet,
A.N. Stone,
J.B. Eastwood,
期刊:
Nephron
(Karger Available online 1984)
卷期:
Volume 36,
issue 2
页码: 131-135
ISSN:1660-8151
年代: 1984
DOI:10.1159/000183133
出版商: S. Karger AG
关键词: Vitamin A;Calcium homeostasis;Bone disease;Chronic renal failure
数据来源: Karger
摘要:
A study has been made of possible interrelationships between circulating vitamin A concentration and indicators of altered calcium homeostasis in 31 patients with stable chronic renal failure. Plasma retinol concentrations were high, possibly as a result of increased retinol-binding-protein concentrations secondary to renal failure. There was no correlation between retinol concentration and any other measurement, including vitamin A intake. However, there were significant correlations between plasma parathyroid hormone and calcium, phosphate, alkaline phosphatase, urea, and creatinine concentrations; and those patients with radiological sub-periosteal erosions tended to have the highest concentrations of circulating parathyroid hormone. Our data give no support to the contention that vitamin A status has any bearing on the progression and severity of the hyperparathyroid bone disease of renal failure.
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