SUMMARY1. The metabolic fate of the insoluble bile acid sequestrant polidexide, (poly‐[2‐(diethylamino)ethyl] polyglycerylenedextran hydrochloride), was studied in four adult humans following the oral administration of the14C‐labelled substance.2. The mean cumulative recovery of14C in faeces was 95·3% (s.e.m. = 1·1) of the administered dose, while mean cumulative recovery in urine was 0·37% (s.e.m. = 0·13) of the oral dose.3. Only background levels of radioactivity were detectable in plasma samples taken 1·3 days after administration of tracer.4. The findings suggested that polidexide was not absorbed from the gastrointestinal tract in man to any signific