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β-lumicolchicine as a Tool to Elucidate Microtubular Function in Dentinogenesis

 

作者: DahlJon Einar,   SteneTorbjørn,   KoppangHanna Strømme,   KoppangRolf,   StokkeTorvald,  

 

期刊: Acta Odontologica Scandinavica  （Taylor Available online 1981）
卷期: Volume 39, issue 4  

页码: 195-200

 

ISSN:0001-6357

 

年代: 1981

 

DOI:10.3109/00016358109162280

 

出版商: Taylor&Francis

 

关键词: Colchicine derivatives;incisor;irregular dentin;rat;vinca alkaloids

 

数据来源: Taylor

 

摘要:

β-lumicolchicine, an isomer of colchicine which does not interrupt microtubular function, was given to 8 rats in a dose of 1.5 mg/kg. Four rats served as controls. Histomorphological investigations of odontoblasts and dentin in the maxillary incisors after two weeks revealed no disturbances. This finding, compared with the previously reported effects of colchicine, as well as colcemid, vincristine and vinblastine, indicates dentin production to be dependant on microtubules.

 

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