Association of Genes within the Major Histocompatibility Complex with Attention Deficit Hyperactivity Disorder
作者:
Dennis Odell,
Reed P. Warren,
Louise Warren,
Roger A. Burger,
Alma Maciulis,
期刊:
Neuropsychobiology
(Karger Available online 1997)
卷期:
Volume 35,
issue 4
页码: 181-186
ISSN:0302-282X
年代: 1997
DOI:10.1159/000119342
出版商: S. Karger AG
关键词: Attention deficit hyperactivity disorder;Major histocompatibility complex;Human lymphocyte antigens;Complement
数据来源: Karger
摘要:
The objective was to determine whether a relationship exists among the complement C4B gene, a DR region gene and attention deficit hyperactivity disorder (ADHD). Thirty-one subjects with ADHD, their mothers, all but 5 of their fathers, and 90 normal subjects living in northern Utah were studied. DR and C4B typing were performed by serologic HLA typing techniques and the DNA methods PCR-RFLP. The alleles of 2 genes, the null allele of the C4B gene and the β1 allele of the DR gene, encode for products involved in immune function and regulation. Each of these alleles was found to be significantly associated with ADHD. Moreover, approximately 55% of the ADHD subjects carried both of these alleles on 1 of their chromosomes, compared to only 8% of normal controls. Genes related to the immune system may be associated with development of the symptoms of ADHD
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