Cholinomimetic teratogens. V. The effect of oximes and related cholinesterase reactivators
作者:
Walter Landauer,
期刊:
Teratology
(WILEY Available online 1977)
卷期:
Volume 15,
issue 1
页码: 33-42
ISSN:0040-3709
年代: 1977
DOI:10.1002/tera.1420150105
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractPyridine‐2‐aldoxime methiodide and pyridine‐2‐aldoxime methyl methane sulfonate (P2S), used as supplements to carbachol or neostigmine, greatly lowered the incidence in chicken embryos of vertebral defects and muscular hypoplasia. With 4‐pyridine aldoxime the effect of the teratogens was less reduced. Supplementation of carbachol or neostigmine with either ambenonium or toxogonin lessened the occurrence of muscular hypoplasia, but did little, if anything, to prevent malformation of the neck vertebrae. In tests with physostigmine P2S as supplement reduced or prevented cervical defects, but failed to protect the nicotinamide‐sensitive parts of
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