Hypothalamic insulin and neuropeptide Y in the offspring of gestational diabetic mother rats
作者:
Andreas Plagemann,
Thomas Harder,
Annett Rake,
Kerstin Melchior,
Fanny Rittel,
Wolfgang Rohde,
Günter Dörner,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 18
页码: 4069-4073
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Galanin;Gestational diabetes;Hypothalamus;Insulin;Insulin resistance;Neuropeptide Y;Newborn rats
数据来源: OVID
摘要:
THE offspring of diabetic mothers is at increased risk to develop obesity and diabetogenic disturbances during life. Pathophysiological mechanisms responsible are unclear. Neuropeptide Y (NPY) is an important hypothalamic stimulator of food intake and body weight gain, and its levels are decreased by elevated insulin. In neonatally hyperinsulinaemic offspring of diabetic mother rats, hypothalamic insulin level was significantly increased at birth (p< 0.01). At weaning, i.e. at the end of the critical hypothalamic differentiation period, a significantly increased number of NPY-positive neurons (p< 0.01) appeared in the arcuate hypothalamic nucleus. In conclusion, an increase in the number of NPYergic neurons in the hypothalamus, possibly due to hypothalamic malformation and/or perinatally acquired hypothalamic insulin resistance, might contribute to the development of obesity and metabolic disturbances in the offspring of diabetic mothers.
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