Prediction by31P‐NMR of the irreversibility of ischemic injury in rat skeletal muscle after ligation of the femoral artery
作者:
B. Authier,
A. Rossi,
J. P. Albrand,
M. Decorps,
期刊:
Muscle&Nerve
(WILEY Available online 1989)
卷期:
Volume 12,
issue 1
页码: 20-25
ISSN:0148-639X
年代: 1989
DOI:10.1002/mus.880120105
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: skeletal muscle;ischemia;rat in vivo31P‐NMR spectroscopy
数据来源: WILEY
摘要:
AbstractRat leg muscles, rendered ischaemic 1 hour previously by ligation of the femoral artery, were submitted to 20 minutes exercise by electrical stimulation of the sciatic nerve.31P‐NMR spectroscopy was used to monitor the changes in high‐energy phosphate content of the muscles before, during, and after exercise. Fifteen of the 35 studied muscles evolved toward total necrosis, whereas the others showed signs of recovery over a 2–5‐hour postexercise period. Those muscles which did not subsequently recover contained significantly more inorganic phosphate (Pi) at rest (before exercise) than those which recovered. It is suggested that under acute ischaemic conditions the Pilevel at rest is correlated with the extent of blood flow restriction and can be used to predict the severity of the i
点击下载:
PDF
(445KB)
返 回