Increased expression of the CD45RO (memory) antigen on T cells in HIV‐infected children
作者:
Karin Froebel,
Kathleen Doherty,
James Whitelaw,
Rosemary Hague,
Jacqueline Mok,
A. Bird,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 1
页码: 97-100
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: Paediatric HIV infection;leucocyte common antigen;cell-mediated immunity;phenotypic markers
数据来源: OVID
摘要:
Expression of the CD45RO putative memory cell antigen on CD4 (helper) and CD8 (cytotoxic/suppressor) lymphocytes of children born to HIV-infected women was investigated using the UCHL 1 antibody. Significantly raised numbers of CD45RO + CD8 lymphocytes were found in all nine of the infected children compared with uninfected and control children. Expression of CD45RO on CD4 lymphocytes was variable; absolute numbers were not increased, although the percentage was increased in four out of nine infected children. All the infected children except two (who had comparatively low numbers of CD45RO+ CD8 cells) were clinically well, which suggests that an increase in CD45RO + CD8 cells may be indicative of a functionally active immune response against HIV.
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