Psychosensory Symptoms in Bipolar Disorder
作者:
S. Ali,
Kirk Denicoff,
Terence Ketter,
Earlian Smith-Jackson,
Robert Post,
期刊:
Neuropsychiatry, Neuropsychology & Behavioral Neurology
(OVID Available online 1997)
卷期:
Volume 10,
issue 4
页码: 223-231
ISSN:0894-878X
年代: 1997
出版商: OVID
关键词: Bipolar disorder;Psychosensory;Diagnosis;Lithium;Carbamazepine
数据来源: OVID
摘要:
SummaryThis study investigated psychosensory symptoms and their relationship to retrospective and prospective courses of illness, as well as therapeutic outcomes, in patients with bipolar disorder. Using the Silberman-Post Psychosensory Rating Scale (SP-PSRS), psychosensory symptoms were assessed in 51 patients who met Diagnostic and Statistical Manual, 3rd Edition-Revised (DSM-III-R) criteria for bipolar disorder and in 39 healthy, normal controls. Patients with bipolar disorder were enrolled in a 3-year, double-blind, randomized study comparing the prophylactic efficacy of lithium or carbamazepine in the first year, a crossover to the other drug in the second year, and the combination of both medications in the third year. Psychosensory scores from patients with bipolar disorder were compared with scores from healthy controls and with a variety of retrospective and prospective course of illness and treatment variables. Psychosensory symptoms occurred frequently in patients with bipolar I and II disorders, but were rare in healthy controls. When depressed, patients with bipolar II disorder (n= 23) reported more psychosensory symptoms when compared to patients with bipolar I disorder (n= 28), and those with a history of rapid cycling (n= 29) reported more psychosensory symptoms when compared to patients without a history of rapid cycling (n= 21). Psychosensory symptoms were not related to response to carbamazepine, lithium, or the combination of both drugs. Although the presence of psychosensory symptoms is associated with some bipolar subtypes (patients with bipolar II disorder and patients with a history of rapid cycling), they do not appear to predict treatment response. Further studies are needed to assess the pathophysiologic implications of the presence of psychosensory symptoms and their potential implications, if any, for directing therapeutics.
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