Invited review: Guidance cue patterns and cell migration in muiticeliuiar organisms
作者:
Michael J. Katz,
Raymond J. Lasek,
期刊:
Cell Motility
(WILEY Available online 1980)
卷期:
Volume 1,
issue 1
页码: 141-157
ISSN:0271-6585
年代: 1980
DOI:10.1002/cm.970010111
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: axon guidance;chemotaxis;haptotaxis substrate pathways;development;pattern biology
数据来源: WILEY
摘要:
AbstractIn multicellular organisms, guidance cues are either diffusible molecules or cellular or extracellular surfaces that are found in reproducible locations and that orient migrating cells and cell processes. The pattern of the guidance cues usually determines the complex in vivo migration routes of motile cells and cell processes. Within organisms, guidance cues are found to be organized in two general patterns: (a) broad gradients ‐ such as diffuse chemotactic gradients; (b) discrete routes (substrate pathways) ‐ such as chemotactic gradients confined to long channels, and such as the axon surface which represents a long specific highway for migrating Schwann ce
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