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Synthesis of suicide inhibitors of monoamine oxidase: Carbon‐11 labeled clorgyline, L‐deprenyl and D‐deprenyl

 

作者: R. R. Macgregor,   J. S. Fowler,   A. P. Wolf,   C. Halldin,   B. Langström,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1988）
卷期: Volume 25, issue 1  

页码: 1-9

 

ISSN:0362-4803

 

年代: 1988

 

DOI:10.1002/jlcr.2580250102

 

出版商: John Wiley&Sons, Ltd.

 

关键词: [11C]Clorgyline;[11C]‐L‐Deprenyl;[11C]‐D‐Deprenyl;Monoamine Oxidase A and B;Suicide Inhibitors

 

数据来源: WILEY

 

摘要:

AbstractThe suicide inhibitors of monoamine oxidase type A and B, clorgyline and L‐deprenyl have been labeled with carbon‐11 by [11C]methylation of the norbases with [11C]H3I. The less active enantiomer of deprenyl (D‐deprenyl) was also labeled using this procedure. The synthesis time was 35 minutes, the radiochemical yield was 25–40% and the specific activity was 0.8–2.0 Ci/μmol (calculated to EOB). Procedures for synthesis of the precursor norbases as well as the synthesis of unlabeled clorgyline, L‐deprenyl and D‐depr

 

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