Combination Therapy with Interferon-α and Ribavirin for Hepatitis CPractical Treatment Issues
作者:
Jane Collier,
Roger Chapman,
期刊:
BioDrugs
(ADIS Available online 2001)
卷期:
Volume 15,
issue 4
页码: 225-238
ISSN:1173-8804
年代: 2001
出版商: ADIS
关键词: Antivirals, therapeutic use;Hepatitis C, treatment;Interferon alpha, therapeutic use;PEG interferon alpha 2a, therapeutic use;PEG interferon alpha 2b, therapeutic use;Research and development;Ribavirin, therapeutic use
数据来源: ADIS
摘要:
Combination therapy with ribavirin and interferon (IFN)-α for 6 to 12 months is currently the treatment of choice for chronic hepatitis C infection. The overall sustained response rate to treatment, defined as loss of hepatitis C virus (HCV) from serum 6 months after completion of treatment, is 40%. The indications for treatment are serum HCV RNA positivity, abnormal serum transaminases and the presence of portal fibrosis and/or moderate/severe inflammation.Response rates are lower in genotype 1 than in genotype 2 or 3 and in the presence of a high viral load. Anaemia is the most common adverse event and is due to ribavirin; neuropsychiatric adverse effects due to IFNα lead to premature cessation of therapy in 10 to 20% of patients.The current recommended dose of interferon is 3MU given subcutaneously 3 times a week. However, it is likely that longer-acting pegylated interferons, which may be more effective and can be administered once weekly, will in the future replace currently used IFNα.
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