Soluble Interleukin-2 Receptor Secretion Defectin Vitroin HLA-B8, DR3 Positive Subjects
作者:
ModicaMaria Assunta,
LorenzoGabriele Di,
GalluzzoAldo,
GiordanoCarla,
PortelliMaria Rita,
CandoreGiuseppina,
CarusoCalogero,
期刊:
Autoimmunity
(Taylor Available online 1990)
卷期:
Volume 7,
issue 2-3
页码: 87-96
ISSN:0891-6934
年代: 1990
DOI:10.3109/08916939008993381
出版商: Taylor&Francis
关键词: T cells;HLA-BS.DR3;autoimmunity;slL-2R
数据来源: Taylor
摘要:
Several studies have shown that HLA-B8,DR3 positive subjects may display T cell dysfunctions. Recently, a soluble form of the receptor for IL-2 (sIL-2R) has been demonstrated in human sera and in vitro-stimulat-ed culture supernatants from human T lymphocytes. In the present paper we report sIL-2R serum levels and sIL-2R production from peripheral blood mononuclear cells in HLA-B8,DR3 positive subjects. We found that HLA-B8.DR3 positive subjects have the highest values of serum sIL-2R. but comparing the values of these subjects with those of negative ones no significant difference was observed. As regards the in vitro production of sIL-ZR, no difference exists for unstimulated cultures, whereas after stimulation, the HLA-B8,DR3 positive subjects showed the lowest values compared with negative ones. It is noteworthy that these changes are observed in autoimmune diseases linked to this HLA phenotype.
点击下载:
PDF (562KB)
返 回