Low Incidence of Toxic Shock Syndrome in Children with Staphylococcal Infection
作者:
JAY JACOBSON,
EVELYN KASWORM,
RAOUL REISER,
MERLIN BERGDOLL,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1987)
卷期:
Volume 294,
issue 6
页码: 403-407
ISSN:0002-9629
年代: 1987
出版商: OVID
关键词: Toxic Shock Syndrome;Septic Shock;Staphylococcal Infections;Staphylococcus Aureus
数据来源: OVID
摘要:
Children have frequent staphylococcal infections, and many lack antibody to TSST-1, a toxin associated with the toxic shock syndrome (TSS). To determine why there have been no nonmenstrual cases of TSS reported in children in Utah, the authors testedS. aureusisolated from children for TSST-1 by radial immunodiffusion and sera from other hospitalized children by radioimmunoassay for antibody to TSST-1. TSST-1 was produced by 25% ofS. aureus. Fifty-two children had infections with toxin producing strains. None had TSS. The prevalence of presumably protective levels of antibody (⩾1: 100) was high in newborns (80%), declined until age 2 years and then gradually increased with age. Therefore, there may have been about 20 children with toxigenic infection who lacked protective antibody but did not show the usual features of TSS. We conclude that the rarity of TSS in children is not caused by misdiagnosis, underreporting, or the absence of toxigenic strains or susceptible patients. Additional factors, such as local conditions or duration of carriage, may influence the clinical presentation of infection with TSST-1 producing staphylococci.
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