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Region II of theHaemophilus influenzaeType b capsulation locus as involved in serotype‐specific polysaccharide synthesis

 

作者: Johan Eldere,   Lisa Brophy,   Barbara Loynds,   Patrick Celts,   Ian Hancock,   Stephen Carman,   J. Simon Kroll,   E. Richard Moxon,  

 

期刊: Molecular Microbiology  (WILEY Available online 1995)
卷期: Volume 15, issue 1  

页码: 107-118

 

ISSN:0950-382X

 

年代: 1995

 

DOI:10.1111/j.1365-2958.1995.tb02225.x

 

出版商: Blackwell Publishing Ltd

 

数据来源: WILEY

 

摘要:

SummaryThe central (serotype‐specific) Region II of theHaemophilus influenzaeType b capsulation locuscapis 8.3 kb long and contains a cluster of four genes. We show that these genes, designatedorf1toorf4, are involved in the biosynthetic steps required for the formation of the Type b capsular polysaccharide and thatorf1probably encodes a CDP‐ribitolpyrophosphorylase. We present evidence that growth of polysaccharide chains takes place through the alternating addition of single sugar nucleoti

 

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