Region II of theHaemophilus influenzaeType b capsulation locus as involved in serotype‐specific polysaccharide synthesis
作者:
Johan Eldere,
Lisa Brophy,
Barbara Loynds,
Patrick Celts,
Ian Hancock,
Stephen Carman,
J. Simon Kroll,
E. Richard Moxon,
期刊:
Molecular Microbiology
(WILEY Available online 1995)
卷期:
Volume 15,
issue 1
页码: 107-118
ISSN:0950-382X
年代: 1995
DOI:10.1111/j.1365-2958.1995.tb02225.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SummaryThe central (serotype‐specific) Region II of theHaemophilus influenzaeType b capsulation locuscapis 8.3 kb long and contains a cluster of four genes. We show that these genes, designatedorf1toorf4, are involved in the biosynthetic steps required for the formation of the Type b capsular polysaccharide and thatorf1probably encodes a CDP‐ribitolpyrophosphorylase. We present evidence that growth of polysaccharide chains takes place through the alternating addition of single sugar nucleoti
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