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Prostaglandin F2αImproves Oxygen Tension and Reduces Venous Admixture during One‐lung Ventilation in Anesthetized Paralyzed Dogs

 

作者: R. Scherer,   G. Vigfusson,   E. Hultsch,   H. Aken,   P. Lawin,  

 

期刊: Anesthesiology  (OVID Available online 1985)
卷期: Volume 62, issue 1  

页码: 23-28

 

ISSN:0003-3022

 

年代: 1985

 

出版商: OVID

 

关键词: Lung: hypoxic pulmonary vasoconstriction;hunting;Pharmacology: Prostaglandin F2α;Ventilation: one lung

 

数据来源: OVID

 

摘要:

The authors investigated the effect of prostaglandin F2αinfused into the pulmonary artery of an acutely atelectatic lung in dogs. Seven dogs were anesthetized with piritramid and pentobarbital and intubated with a Kottmeier canine endobronchial tube. Cardiac output, pulmonary arterial, capillary wedge, and systemic arterial pressure were measured via indwelling catheters. Ventilating both lungs with 66% O2, Pao2was 327±15 mmHg (mean±SD) and venous admixture (Q±sp/Q1) was 11±3%. One-lung atelectasis reduced Pao2to 91±12 mmHg and increased Q±sp/Qtto 40±4%. Prostaglandin F2αin doses of 0.4, 0.6, 1.2, and 1.8 μg ± kg−1· min−1was infused into the pulmonary artery of the atelectatic lung through a second pulmonary artery catheter. Up to a dose of 1.2 μg · kg−1· min−1there was a dose-dependent reduction in Q·sp/Qtto a minimum of 25±4% and an increase in Pao2to 168±25 mmHg, which could be explained by enhanced pulmonary vasoconstriction in the atelectatic lung with increased blood flow diversion toward the ventilated lung. Infusion of 1.8 μg · kg−1· min−1decreased Pao2to 156±32 mmHg and increased Q±sp/Qtto 32±9%. Increased systemic effects of prostaglandin F2αwere observed and presumably were related to saturation of prostaglandin-dehydrogenase leading to vasoconstriction in both lungs and thus reduced blood flow diversion toward the ventilated lung.

 

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