Effect of Perphenazine on Secretory Patterns of Growth Hormone in the Rat
作者:
Geoffrey P. Redmond,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 30,
issue 4
页码: 243-248
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123008
出版商: S. Karger AG
关键词: Perphenazine;Phenothiazines;Growth hormone;Growth;Effects of drugs
数据来源: Karger
摘要:
A nonstressful frequent sampling technique was employed to determine the effect of perphenazine, 5 mg/kg on spontaneous secretion of rat growth hormone (rGH). The drug blocked secretion almost entirely for at least 3, but no more than 22 h. These results suggest a role for dopamine and/or norepinephrine as stimulatory neurotransmitters for spontaneous rGH secretory episodes. They further suggest that experimental or therapeutic use of phenothiazines might produce functional GH deficiency.
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