Reinvestigation of the Polonovski reaction. Synthesis of deuterated dimethylamine and formaldehyde
作者:
R. N. Renaud,
L. C. Leitch,
期刊:
Canadian Journal of Chemistry
(NRC Available online 1968)
卷期:
Volume 46,
issue 3
页码: 385-390
ISSN:0008-4042
年代: 1968
DOI:10.1139/v68-061
出版商: NRC Research Press
数据来源: NRC
摘要:
Dimethylaminomethyl acetate, a postulated intermediate in the Polonovski reaction, has been isolated for the first time in 80% yield from the reaction between trimethylamineN-oxide and one equivalent of acetic anhydride. With more acetic anhydride the dimethylaminomethyl ester gaveN,N-dimethyl acetamide and two other products which have been identified as 2-(dimethylaminornethyl)acrylic acid and 2,2-bis(acetoxymethyl)-3-(dimethylamino)propionic acid. The manner of formation of these two products has been clarified by using deuterium and13C labelled reagents.Hydrolysis of deuterated dimethylaminomethyl acetate prepared from trimethyl-d9amineN-oxide and acetic anhydride gave satisfactory yields of dimethyl-d6amine and formaldehyde-d2.
点击下载:
PDF
(387KB)
返 回