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Estimation of Renal Tubular Secretion in Man, in Health and Disease, Using Endogenous N-1-Methylnicotinamide

 

作者: A. Maïza,   S. Waldek,   F.W. Ballardie,   P.T. Daley-Yates,  

 

期刊: Nephron  (Karger Available online 1992)
卷期: Volume 60, issue 1  

页码: 12-16

 

ISSN:1660-8151

 

年代: 1992

 

DOI:10.1159/000186698

 

出版商: S. Karger AG

 

关键词: Clearance of creatinine;Clearance of N-1-methylnicotinamide;Man;Glomerulo-tubular imbalance;Measurement of tubular secretion

 

数据来源: Karger

 

摘要:

We have been investigating the possibility of using the renal clearance of endogenous N-1-methylnicotinamide (NMN) as a marker of renal tubular function. Sixty-three subjects (11 healthy volunteers and 52 patients with renal impairment) were used for this study. The subjects were divided into three groups according to their creatinine clearance: group 1, over 80 ml/min; group 2, between 30 and 80 ml/min, and group 3, less than 30 ml/min. The correlation between NMN and creatinine clearance was compared for each group. A good correlation (r = 0.84) was found for groups 1 and 3 (r = 0.76), whereas for group 2, a poor correlation was found (r = 0.43). For subjects with mild renal impairment (group 2), there was clear evidence of glomerulo-tubular imbalance manifest by a larger variability in NMN clearance than creatinine clearance and an essentially non-parallel decline in these two parameters for this group. When all subjects were grouped together, the relationship between the clearance of NMN and of creatinine was best described by a 3-term polynomial equation (r = 0.93). NMN clearance is a potentially useful non-invasive marker of renal tubular function in man and provides additional information to that provided by the measurement of creatinine clearance alone. This substance should be more fully evaluated as a potential diagnostic aid.

 

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