Importance of hepatic neoplasms in lower vertebrate animals as a tool in cancer research
作者:
T. Ishikawa,
S. Takayama,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1979)
卷期:
Volume 5,
issue 2-3
页码: 537-550
ISSN:0098-4108
年代: 1979
DOI:10.1080/15287397909529765
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Hepatic tumors were induced in medakas (Oryzias latipes) by the addition of diethylnitrosamine (DEN) to their aquarium water. Medakas are useful for study because they are highly susceptible to the carcinogenic effect of DEN and the time for tumor induction is relatively short. Tumors had a histological pattern similar to that of mammalian hepatic tumors. The medaka seems to be susceptible to water‐soluble carcinogens.
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