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Subchronic inhalation toxicity of 1,3‐dichloropropene/1,2‐dichloropropane...
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Subchronic inhalation toxicity of 1,3‐dichloropropene/1,2‐dichloropropane (D‐D) in mice and rats
作者:
C. M. Parker,
W. B. Coate,
R. W. Voelker,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1982)
卷期:
Volume 9,
issue 5-6
页码: 899-910
ISSN:0098-4108
年代: 1982
DOI:10.1080/15287398209530212
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Groups of 28 male and 28 female CD‐1 mice and Fischer 344 rats were exposed to a mixture of 1,3‐Dichloropropene and 1,2‐Dichloropropane (D‐D) vapors. Exposure concentrations were 0, 5 (4.7), 15 (14.4), or 50 (53.7) ppm, 6 h/d, 5 d/wk for 6 or 12 wk. The following parameters were evaluated: pharmacotoxic signs, body weights, hematology (HGB, HCT, RBC, WBC, and diff. leukocyte count), serum chemistry (BUN, GLU, ALB, GPT, and ALP), urinalysis, gross pathology, histopathology, organ weights, and organ weight/body weight ratios of brain, heart, liver, kidneys, testes or ovaries, and adrenals. The only exposure‐related clinical effects observed were increased mean liver/body weight ratios of male rats and mean kidney/body weight ratios of female rats at the 50 ppm exposure level. Slight to moderate diffuse hepatocytic enlargement in 12 of 21 of the 50‐ppm male mice after 12 wk exposure was the only compound‐related histopathologic change present.
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