AbstractA new sequential continuous chromatographic refiner (SCCR‐2) for high temperature production scale G.L.C. (gas‐liquid chromatographic) separations is described. In this equipment the counter‐current movement between the gas and liquid phase is simulated by sequencing a system of inlet and outlet port functions around twelve static 2.54 cm internal diameter and 61 cm long stainless steel columns. The versatility of the equipment has been demonstrated by the separation of equivolume mixtures of the halocarbons arklone P/genklene P, methylchloroacetate/ethyl lactate and ethyl caprate/ethyl laurate at temperatures of 60°, 105° and 160°C respectively. Throughputs between 21–75 cm3h−1have been explored with product purities in excess of 99.8% achieved under certain proces