An Improved Synthesis of 3-Methyl-5-hydroxy Protected Indoles
作者:
JosephP. Marino,
ClarenceR. Hurt,
期刊:
Synthetic Communications
(Taylor Available online 1994)
卷期:
Volume 24,
issue 6
页码: 839-848
ISSN:0039-7911
年代: 1994
DOI:10.1080/00397919408011306
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The synthesis of 3-methyl-5-alkoxy indoles14and15was accomplished through the use of DIBALH to effect the reductive-cyclization of an amino-nitrile intermediate. The mild conditions used to induce cyclization allowed for the use of a benzyl protecting groups which is normally sensitive to palladium catalyzed reducing conditions.
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