Age-Related ANP Release in Response to Acute vs. Chronic Sodium Loading
作者:
WeissgartenJ.,
AverbukhZ.,
BermanS.,
GolikA.,
CohnM.,
CohenD.,
CohenN.,
ModaiD.,
期刊:
Renal Failure
(Taylor Available online 1995)
卷期:
Volume 17,
issue 1
页码: 37-41
ISSN:0886-022X
年代: 1995
DOI:10.3109/08860229509036373
出版商: Taylor&Francis
关键词: Aging;Atrial natriuretic peptide;Salt load
数据来源: Taylor
摘要:
Atrial natriuretic peptide (ANP) levels were studied in young (2-week-old) and old (age 20 months) rats following acute (20 mL/kg bolus of normal saline i.v.) vs. chronic sodium loading (high-salt diet for 21 days). In both groups serum ANP rose significantly 1 h post i.v. loading. However, the increment was greater in the old animals. On chronic sodium load, in the young group, ANP rose significantly on days 3 and 7, subsequently declining to baseline. In the old animals, no increase in ANP was noted throughout the chronic experiment. Twenty-four-hour urinary sodium excretion was similar in the two groups following acute or chronic salt load. The results suggest that: (1) The old kidney requires a greater ANP stimulus to excrete a given acute i.v. sodium load. (2) The relatively diminished elasticity of the old heart plays a major role in the exaggerated ANP release in response to a bolus i.v. load of saline. (3) The role of ANP in maintaining homeostatic renal sodium excretion during short-term sodium oral loading is different in the two age groups.
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