Quantitation of HIV‐1 Proviral DNA in Cells from Cerebrospinal Fluid
作者:
Harry Steuler,
Sabine Munzinger,
Brigitte Wildemann,
Brigitte Storch-Hagenlocher,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1992)
卷期:
Volume 5,
issue 4
页码: 405-408
ISSN:0894-9255
年代: 1992
出版商: OVID
关键词: Human immunodeficiency virus type 1;Cerebrospinal fluid;Polymerase chain reaction
数据来源: OVID
摘要:
The number of proviral copies in the cerebrospinal fluid of 13 patients in various stages of HIV-1 infection was determined using the polymerase chain reaction. HIV-1 proviral DNA was detected at a median value of 1 provirus per 300 cells with a range from 1 per 20 to 1 per 2,400 cells and a mean value of 1 provirus per 570 cells. Interestingly, this indicates a higher proportion of infected cells in cerebrospinal fluid than is reported to be the case for blood mononuclear cells. However, a clear correlation of these findings to the CDC stage or to neurologic complications was not obvious.
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