Vasodepressor Role of Endogenous Bradykinin Assessed by a Bradykinin Antagonist
作者:
ATHANASSIOS BENETOS,
HARALAMBOS GAVRAS,
JOHN STEWART,
RAYMOND VAVREK,
SIMON HATINOGLOU,
IRENE GAVRAS,
期刊:
Hypertension
(OVID Available online 1986)
卷期:
Volume 8,
issue 11
页码: 971-974
ISSN:0194-911X
年代: 1986
出版商: OVID
关键词: experimental renovascular hypertension;converting enzyme inhibitor;saralasin;sodium nitroprusside
数据来源: OVID
摘要:
This study was designed to examine the contribution of bradykinin to the depressor effect of different antihypertensive drugs in two-kidney renovascular hypertensive rats, using a new specific antagonist of bradykinin. First, the inhibitory capacity of this peptide for exogenously injected bradykinin (75–200 ng) was tested. An inhibition of the vasodepressor action of bradykinin by over 50% was found when the bradykinin inhibitor was infused at a rate of 40 μg/min, with little difference at higher rates of infusion. This inhibitor then was infused in three groups of renovascular hypertensive rats after their blood pressure had been decreased by pretreatment with the converting enzyme inhibitor enalapril (MK 421), saralasin, or sodium nitroprusside, respectively. Infusion of the inhibitor produced an immediate 30% increase in blood pressure only in the enalapril-treated group. These results indicate that bradykinin is involved in the decrease of blood pressure produced by converting enzyme inhibition in experimental renovascular hypertension.
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