ApoE4 Polymorphism Increases the Risk for Exercise‐Induced Silent Myocardial Ischemia in Older Men
作者:
Leslie Katzel,
Jerome Fleg,
Michael Paidi,
Nyla Ragoobarsingh,
Andrew Goldberg,
期刊:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
(OVID Available online 1993)
卷期:
Volume 13,
issue 10
页码: 1495-1500
ISSN:1049-8834
年代: 1993
出版商: OVID
关键词: apoE;silent ischemia;atherosclerosis;aging;exercise treadmill test
数据来源: OVID
摘要:
The apolipoprotein (apo) E4 polymorphism is associated with increased risk for symptomatic coronary artery disease (CAD). This study examines whether the apo«4 allele is associated with an increased risk for exercise-induced silent myocardial ischemia (SI) in healthy, older (62 ±7 years; mean±SD), normocholesterolemic, nonsmoking male volunteers. The apoe4 allele was present in 20 of 45 (44%) men with SI on graded exercise treadmill testing compared with 22 of 127 (17%) men of comparable age with normal exercise testsp><.001), resulting in a crude relative risk of 2.57 (95% confidence limits, 1-57 to 4.23) for SI in men with the apoe4 allele compared with those without theeXallele. Although the lipoprotein lipid levels did not differ between men with normal exercise tests and those with SI, the men with the apoE 4/3 phenotype had higher total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels than those with the apoE 2/3 and 3/3 phenotypes (p<.05). Men with SI and the apoE 4/3 phenotype were older (64±5 versus 57±8 years,p<.01) and leaner (p<.01) than the normal non-SI men with the apoE 4/3 phenotype. The older age of the men with SI and the apoE 4/3 phenotype is consistent with a progression of atherosclerosis over time. Men with SI and the apoE 3/3 phenotype were of comparable age and body composition to apoE 3/3 phenotype men with normal exercise tests. Thus, even in the presence of normal LDL-C levels, the apoe4 allele may predispose older men to SI.
点击下载:
PDF
(413KB)
返 回