A comparison of hydrocortisone and triamcinolone inhibition of scale and feather development
作者:
Cynthia J. Fisher,
Roger H. Sawyer,
期刊:
Teratology
(WILEY Available online 1986)
卷期:
Volume 33,
issue 1
页码: 37-45
ISSN:0040-3709
年代: 1986
DOI:10.1002/tera.1420330107
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractHydrocortisone (30–40 μg on day 10) and triamcinolone (10–20 ng on day 7–8) both inhibit or alter morphogenesis of scales and feathers. However, there are marked temporal and region‐specific differences in the effects induced by these two glucocorticoids. Triamcinolone (TAC) is most teratogenic on day 7 or 8, inhibiting formation of spurs and feathers and inducing club feather formation. Hydrocortisone is most teratogenic later in development, on day 10. Unique hydrocortisone‐induced responses are complete inhibition of scutellate scale formation, bent feathers, and apteria around the external auditory meatus. Altered synthesis of keratin polypeptides follows inhibition of scale morphogenesis by hydrocortisone and TAC. These in vivo data suggest that heterogeneity of glucocorticoid binding occurs in embryonic chick metatarsal skin. Survival data indicate that TAC is 2,000 times more embryotoxic than hydr
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