APPARENT NON-FICKIAN RELEASE FROM A SCLEROGLUCAN GEL MATRIX
作者:
MARIO GRASSI,
ROMANO LAPASIN,
SABRINA PRICL,
ITALO COLOMBO,
期刊:
Chemical Engineering Communications
(Taylor Available online 1996)
卷期:
Volume 155,
issue 1
页码: 89-112
ISSN:0098-6445
年代: 1996
DOI:10.1080/00986449608936658
出版商: Taylor & Francis Group
关键词: Controlled release;scleroglucan hydrogel;kinetics;non-Fickian behavior
数据来源: Taylor
摘要:
Hydrogels, and particularly biopolymeric hydrogels, have recently received tremendous interest as controlled release systems for their peculiar features such as high biocompatibility, biodegradability, bioadhesivity, chemical and thermal resistance and good mechanical properties. Among biopolymers, the exocellular microbial polysaccharide scleroglucan appears to be particularly well suited for the formulation of monolithic hydrogel matrices for controlled drug release. In this work we studied the macroscopic factors influencing the kinetics of a model drug release (theophylline) from a scleroglucan hydrogel matrix (2%w/w) and modeled the relevant experimental results. The evidences for the release experiments indicate that the kinetics of the processes follow an apparently non-Fickian behavior under different active drug concentration, temperature and stirring speed. However, by considering the peculiar nature of the hydrogel matrix and the geometrical features of the experimental setup in the formulation of the appropriate initial and boundary conditions, data can be satisfactorily modeled with the classical Fick's law.
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