Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting
作者:
J.E. Wilson,
R.C. Eberhart,
A.B. Elkowitz,
期刊:
Journal of Macromolecular Science: Part A - Chemistry
(Taylor Available online 1981)
卷期:
Volume 16,
issue 4
页码: 769-782
ISSN:0022-233X
年代: 1981
DOI:10.1080/00222338108056824
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Gamma rays from60Co were used to graft chloromethylstyrene on samples of polysilicone, followed by quaternization with pyridine, then reaction with sodium heparin to replace chloride ions in the samples with heparin anions. Extraction tests on the heparinized samples with normal saline solution showed a maximum heparin removal rate of 5 × 10−-8g/cm2/min. The heparinized polysilicone was found to be more blood compatible than untreated polysilicone in a rabbit ex vivo bleeding test.
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