Reversible Bronchial Hyperresponsiveness Induced by OK-T3/IL-2 Administration in a Patient with Multiple Myeloma
作者:
Giovanni Rolla,
Caterina Bucca,
Luisa Brussino,
Massimo Massaia,
Daniela Bergandi,
期刊:
Respiration
(Karger Available online 1995)
卷期:
Volume 62,
issue 4
页码: 228-231
ISSN:0025-7931
年代: 1995
DOI:10.1159/000196452
出版商: S. Karger AG
关键词: OK-T3/IL-2;IL;2;Bronchial hyperresponsiveness
数据来源: Karger
摘要:
Severe bronchial hyperresponsiveness to methacholine developed after intravenous therapy with OK-T3 and IL-2 in a patient with multiple myeloma, in whom no factors known to be associated with bronchial hyperresponsiveness were present. A substantial increase and activation of peripheral T-lymphocytes was observed after immunotherapy. Bronchial responsiveness and lymphocyte subsets both returned to normal baseline values 2 months after the patient was shifted to subcutaneous low dose administration of IL-2. The strict association between peripheral T-lymphocytes activation and the development of bronchial hyperresponsiveness suggests a causal relationship.
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