Monocyte mediated cytotoxic activity against melanoma
作者:
A. te Velde,
C. Figdor,
期刊:
Melanoma Research
(OVID Available online 1992)
卷期:
Volume 1,
issue 5
页码: 303-310
ISSN:0960-8931
年代: 1992
出版商: OVID
关键词: Cytotoxicity;macrophage;melanoma;monocyte.
数据来源: OVID
摘要:
The appearance of macrophages in human tumours, the so called tumour-infiltrating or tumour-associated macrophages (TIM or TAM) has suggested a role for these cells in host defence mechanisms against cancer.1–4in this review we discuss monocyte-mediated cytotoxic activity against melanoma, as reported by a number of different authors. Although most studies described in this review have used melanoma cell lines as targets for monocyte/macrophage cytotoxicity, it would be incomplete if cytotoxicity against other target cells such as K562 or WEHI-164 is not discussed. At least two distinct mechanisms of killing by monocytes/macrophages can be distinguished; direct recognition and cytotoxicity by the effector cells and antibody-mediated lysis of the tumour cells (antibody-dependent cellular cytotoxicity, ADCC). Both types of cytotoxicity will be discussed.
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