Characterization of Albunex®
作者:
Harold B. Levene,
Robert Moision,
Elaine Villapando,
Jay Torgerson,
Jack Maniquis,
Reinette Kleinhenz,
Randy Keen,
James L. Barnhart,
期刊:
The Journal of the Acoustical Society of America
(AIP Available online 1990)
卷期:
Volume 87,
issue S1
页码: 69-70
ISSN:0001-4966
年代: 1990
DOI:10.1121/1.2028331
出版商: Acoustical Society of America
数据来源: AIP
摘要:
Albunex® is an ultrasound contrast agent prepared by sonicating 5% human serum albumin to produce stable, air‐filled, albumin microspheres. It is an effective ultrasound contrast agent for use with echocardiography and other ultrasound radiology procedures. The characteristics of Albunex that are responsible for the clinically observed high echogenicity of Albunex are discussed. Albunex is composed of a high concentration of noncoalescing microspheres (400–500 μ/nl) with a mean diameter of ≈4 μm and a shell thickness of 30–50 nm, as determined by particle analysis, light microscopy, and electron microscopy. Attenuation and backscatter measurements as a function of ultrasonic frequency and amplitude are reported for varying concentration and size distributions of Albunex.
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