ORG 2766 fails to improve visual functions in rats with occipital lesions
作者:
M. Schmidt,
F. Chirino-Barcelo,
W. McDaniel,
期刊:
NeuroReport
(OVID Available online 1992)
卷期:
Volume 3,
issue 1
页码: 29-32
ISSN:0959-4965
年代: 1992
出版商: OVID
关键词: Neuropeptides;Visual cortex;ACTH analogs;ORG 2766;Recovery of function;Brain damage
数据来源: OVID
摘要:
Adult rats were trained on a white versus black card discrimination in a circular water tank. Three independent variables were manipulated: lesion (sham, lateral occipital, medial occipital), dose of ORG 2766 administered (0 or 25 $mUg in saline on alternate days for 18 days), and time of administration (during the post-surgical recovery interval or during post-operative testing). Both visual cortical lesions produced a prominent retention deficit and defective pattern vision. Neither post-surgical nor concurrent administration of ORG 2766 improved visual functions. These results, along with a growing body of evidence, challenge the generality of the positive influences of ORG 2766 upon behavioral recovery observed in animals with limbic lesions.
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