Determination of Ketamine in Blood Plasma
作者:
Wesley Dill,
Lucy Chucot,
Tsun Chang,
Anthony Glazko,
期刊:
Anesthesiology
(OVID Available online 1971)
卷期:
Volume 34,
issue 1
页码: 73-76
ISSN:0003-3022
年代: 1971
出版商: OVID
关键词: Ketamine;Drug assay;Plasma;Anesthetics
数据来源: OVID
摘要:
A novel assay procedure for ketamine, based upon the extraction of xylene red B into an organic solvent in direct proportion to the amount of ketamine present, is described. Dye concentration is measured by fluorescence, permitting assays in the 0–1 μg range. Some interference by the N-dealkylated metabolite of ketamine was encountered, and other basic drugs may interfere with the assay. With certain limitations, the fluorescent dye procedure appears suitable for clinical application.
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