Chronic Histoplasma capsulatum Infection of the Central Nervous System Successfully Treated with Fluconazole
作者:
I. Tiraboschi,
I. Casas Parera,
R. Pikielny,
G. Scattini,
F. Micheli,
期刊:
European Neurology
(Karger Available online 1992)
卷期:
Volume 32,
issue 2
页码: 70-73
ISSN:0014-3022
年代: 1992
DOI:10.1159/000116794
出版商: S. Karger AG
关键词: Histoplasmosis;Hydrocephalus;Myelopathy;Fluconazole
数据来源: Karger
摘要:
A 48-year-old man with a long-standing history of communicating hydrocephalus is reported. Ventriculoperitoneal shunting led to clinical improvement, but symptoms recurred despite surgical re-exploration switching the shunt to an atrial drainage. Ten months after the last surgical procedure, an acute myelopathy developed. Concomitant pharyngeal granuloma examination identified Histoplasma capsulatum (Hc) yeasts. Despite initial response to amphotericin B, Hc was isolated from cerebrospinal fluid (CSF), valve reservoir and distal catheter after two courses of therapy. Fluconazole successfully sterilized CSF, but transverse myelopathy persisted unchanged, and shunting was needed to control hydrocephalus.
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