Current status of granulocyte transfusions to treat neonatal sepsis
作者:
Ronald G. Strauss,
期刊:
Journal of Clinical Apheresis
(WILEY Available online 1989)
卷期:
Volume 5,
issue 1
页码: 25-29
ISSN:0733-2459
年代: 1989
DOI:10.1002/jca.2920050109
出版商: John Wiley&Sons, Inc.
关键词: neutrophils;neonates;leukapheresis
数据来源: WILEY
摘要:
AbstractNeonates are unusually susceptible to severe bacterial infections. Antibiotic therapy has been supplemented with granulocyte transfusions (GTX) to treat neonatal infections. The precise role of GTX to treat neonatal sepsis is controversial, and 11 reports (including six controlled studies) were critically analyzed. When all data are combined, 79% of 78 neonates receiving antibiotics plus GTX survived vs. 62% of 90 infants treated only with antibiotics. Among the six controlled trials, four found significantly better survival for neonates given GTX plus antibiotics. However, each of these trials can be criticized (few subjects, heterogeneous patients, defective design, inadequate granulocyte product, etc.). Although firm recommendations for GTX cannot be made currently, it seems reasonable to combine them with antibiotics to treat septic neonates that exhibit neutropenia for age and evidence of a diminished neutrophil marrow storage pool. Once the decision to transfuse is made, neonates should receive a minimum dose of 1 × 109fresh neutrophils per kg per transfusion
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