Bilirubin metabolism in canine hepatobiliary and haemolytic disease
作者:
J. Rothuizen,
W. E. van den Brom,
期刊:
Veterinary Quarterly
(Taylor Available online 1987)
卷期:
Volume 9,
issue 3
页码: 235-240
ISSN:0165-2176
年代: 1987
DOI:10.1080/01652176.1987.9694106
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The kinetics of unconjugated3H‐bilirubin are described in 25 healthy dogs and 35 dogs with spontaneous hepatobiliary or haemolytic disease, using a two‐compartment model. The bilirubin production rates from erythrocyte degradation (PE), ineffective erythropoiesis (PI) and catabolism of hepatic haemoproteins (PI), were derived from the incorporation of14C‐glycine into haemoglobin and stercobilin. These combined measurements permitted an integral survey of bilirubin metabolism in health and disease. The concentration of unconjugated bilirubin in plasma and its of total bilirubin levels were similar in hepatic and haemolytic disorders.
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