Superoxide Scavenging Activity of Spin-Labeled Nitrosourea and Triazene Derivatives
作者:
GadzhevaVesselina,
IchimoriKohji,
NakazawaHiroe,
RaikovZahary,
期刊:
Free Radical Research
(Taylor Available online 1994)
卷期:
Volume 21,
issue 3
页码: 177-186
ISSN:1071-5762
年代: 1994
DOI:10.3109/10715769409056568
出版商: Taylor&Francis
关键词: ESR;spin-trap;spin-labeled;nitroxide;nitrosourea;triazene
数据来源: Taylor
摘要:
Superoxide scavenging activities (SSA) of newly synthesized spin-labeled nitrosourea and triazene derivatives, and their precursor nitroxides were investigated by the ESR/spin-trapping method using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and hypoxanthine/xanthine oxidase as the superoxide-generating system. The spin-labeled nitrosoureas, triazenes and their precursor nitroxides exhibited excellent SSA, whereas clinically used nitrosourea and triazene, which do not contain the nitroxide moiety, did not show any SSA. Furthermore, it was deduced that these nitroxides scavenge superoxide by redox cycling between nitroxide and corresponding hydroxylamine.
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