A Combination of Granulocvte Colonv-Stimulating Factor and Erythiopoietin may Synergistically Improve the Anaemia in Patients with Myelodysplastic Syndromes
作者:
HellströmEva,
BirgegårdGunnar,
CarlssonMagnus,
CarneskogJan,
MarieInger,
DybedalIngunn,
GrimforsGunnar,
MerkKarl,
MagnusJon,
WinqvistIngemar,
ÅstÅke,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 11,
issue 3-4
页码: 221-228
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309086999
出版商: Taylor&Francis
关键词: Myelodysplastic syndromes;granulocyte colony-stimulating factor erythropoietin
数据来源: Taylor
摘要:
In an attempt to obtain a synergistic effect on the hemoglobin levels in anaemic patients with myelodysplastic syndromes (MDS), granulocyte colony-stimulating factor (G-CSF) and erythropoietin (epo) were combined in a clinical phase II trial. Twenty-two patients with MDS were included in the study. G-CSF was given alone for six weeks and then in combination with epo for the following twelve weeks. Eight (38%) of 21 evaluable patients showed a significant increase in hemoglobin. One patient with a previous response and subsequent failure to epo alone improved after the addition of G-CSF. Responses were more frequent in patients with less advanced pancytopenia, lower endogenous levels of serum-epo and in those with ring sideroblasts in the bone marrow. The response frequency of 38% is higher than in any study of epo as monotherapy. Moreover, patients with ring sideroblasts, who respond poorly to epo alone, showed a response rate of 60%. Our findings suggest a synergistic in vivo effect of granulocyte-CSF and erythropoietin in patients with myelodysplastic syndromes.
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