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Terconazole 0.8% Vaginal Cream (5 Days) versus Clotrimazole 1% (6 Days): Efficacy and Tolerability in an Open Study

 

作者: H.-G. Siedentopf,  

 

期刊: Gynäkologisch-geburtshilfliche Rundschau  (Karger Available online 1985)
卷期: Volume 25, issue 1  

页码: 33-41

 

ISSN:1018-8843

 

年代: 1985

 

DOI:10.1159/000269986

 

出版商: S. Karger AG

 

关键词: Clotrimazole;Terconazole;Vulvovaginal candidosis

 

数据来源: Karger

 

摘要:

Two groups each of 38 women with cultures positive for Candida on Sabouraud’s medium were studied. One group was given terconazole 0.8% cream for 5 days and the other clotrimazole 1% cream for 6 days. 1 week after treatment cultures from the whole terconazole group were negative for Candida, whereas one in the clotrimazole group was still positive and remained so after 4 weeks. Before treatment 27, 31, and 33 women in the terconazole groups, and 27, 33, and 35 subjects in the clotrimazole group suffered from pruritus, burning and discharge, respectively. 1 week after treatment pruritus and burning had subsided in all women in the terconazole group, but were still present in 3 and 5 patients, respectively, in the clotrimazole group. By that time 10 women on terconazole and 14 on clotrimazole still complained of vaginal discharge. 4 weeks after treatment 1 woman on clotrimazole suffered from pruritus and 2 subjects on terconazole from burning; discharge was still present in 9 patients on terconazole and in 8 on clotrimazole. Results of treatment after 1 week and 4 weeks were considered good to very good for all cases on terconazole and for 37 on clotrimazole; the results for 1 patient on clotrimazole were considered poor. 6 patients on clotrimazole reported burning following application of the cream. To increase the acceptability of antifungal treatment, those drugs with the fewest side-effects, such as burning or unpleasant odour, and which are easiest to apply should be prescribe

 

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