Risk Factors Associated with Persistence of Neuropsychological Deficits in Persons with Organic Solvent Exposure
作者:
LISA MORROW,
CHRISTOPHER RYAN,
MICHAEL HODGSON,
NINA ROBIN,
期刊:
The Journal of Nervous and Mental Disease
(OVID Available online 1991)
卷期:
Volume 179,
issue 9
页码: 540-545
ISSN:0022-3018
年代: 1991
出版商: OVID
数据来源: OVID
摘要:
This study examined neuropsychological prognosis following organic solvent exposure. Twenty-seven persons with evidence of “mild toxic encephalopathy” were evaluated on two separate occasions with a standard neuropsychological test battery and the Minnesota Multiphasic Personality Inventory. Ratings by experienced clinicians revealed that 50% of exposed persons had improved neuropsychological performance at the second evaluation. The other 50% were rated as having no change or a decline in neuropsychological tests scores. While the majority of persons in the good-outcome group were working at the time of the follow-up evaluation, none of the persons in the poor-outcome group was actively employed. Persons rated as having shown no improvement were significantly more likely to have had a peak exposure—an episode in which they were briefly exposed to a larger than normal amount of solvent. In addition, persons in the poor outcome group reported higher levels of psychological distress, both initially and at the follow-up evaluation. Results from this study suggest that the presence of certain risk factors, namely a peak exposure and psychological distress, may be particularly detrimental for long-term neuropsychological outcome in persons with a history of organic solvent exposure.
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