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Factor I (C3b Inactivator) Polymorphism among Five Populations in Eurasia

 

作者: I. Yuasa,   K. Umetsu,   K. Suenaga,   K. Ito,   M. Iha,   H. Hirata,   M. Robinet-Lévy,   T. Lnoue,   K. Okada,  

 

期刊: Human Heredity  （Karger Available online 1988）
卷期: Volume 38, issue 2  

页码: 91-94

 

ISSN:0001-5652

 

年代: 1988

 

DOI:10.1159/000153764

 

出版商: S. Karger AG

 

关键词: Factor I;C3b inactivator;Genetic polymorphism;Population study

 

数据来源: Karger

 

摘要:

Factor I (C3b inactivator) polymorphism in the Japanese (in Western and Southern Japan), Taiwanese, Nepalese and French was studied using isoelectric focusing on polyacrylamide gels. The exposure of passively blotted nitrocellulose membranes to glutaraldehyde vapor facilitated the subsequent immunodetection of a low concentration of factor I and permitted the reliable identification of the three phenotypes determined by two codominant alleles F1*A and FI*B. The data indicated a west-to-east genocline, ranging from France to Western Japan, in which FI*A changed from 0.006 to 0.120.

 

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