Distribution of the admixture test for the detection of linkage under heterogeneity
作者:
Julian J. Faraway,
期刊:
Genetic Epidemiology
(WILEY Available online 1993)
卷期:
Volume 10,
issue 1
页码: 75-83
ISSN:0741-0395
年代: 1993
DOI:10.1002/gepi.1370100108
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: linkage heterogeneity;lod scores
数据来源: WILEY
摘要:
AbstractThe admixture test for the detection of linkage under heterogeneity is considered. We show that the null distribution of this test statistic has half its weight concentrated on zero and the other half on a complicated distribution that can be approximated by max (X1,X2) whereX1andX2are independent χ 12variables. We also investigate the stability of the size of the test for small samples. The power of this test to detect linkage, when heterogeneity is present, can be substantially greater than the standard test that assumes homogeneity. Even when heterogeneity is not present, the test is only slightly less powerful than the homogeneous test. This would suggest the use of the admixture test in preference to the homogeneous test if the presence of heterogeneity is at all suspected. © 1993 Wiley‐Liss
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