Detection of drug‐dependent antibodies by the51cr platelet lysis test: Documentation of immune thrombocytopenia induced by diphenylhydantoin, diazepam, and sulfisoxazole
作者:
Philip L. Cimo,
Anthony V. Pisciotta,
Rajendra G. Desai,
Jose L. Pino,
Richard H. Aster,
期刊:
American Journal of Hematology
(WILEY Available online 1977)
卷期:
Volume 2,
issue 1
页码: 65-72
ISSN:0361-8609
年代: 1977
DOI:10.1002/ajh.2830020109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: drug‐dependent platelet antibodies;drug hypersensitivity;purpura;thrombopenia
数据来源: WILEY
摘要:
AbstractSudden, severe thrombocytopenia developed in each of three patients receiving diphenylhydantoin, diazepam, and sulfisoxazole, respectively. Recovery followed discontinuance of the drugs. An antiplatelet antibody requiring the presence of an appropriate drug for interaction with platelets was demonstrated in each case by the51Cr platelet lysis test using normal, paroxysmal nocturnal hemoglobinuric, or enzyme‐treated normal platelets as target cells. These antibodies could not be detected by techniques that depend on clot retraction inhibition, complement fixation, or platelet factor‐3 activation. Quinine‐ and quinidine‐dependent antiplatelet antibodies in the serum of 16 patients who developed acute thrombocytopenia while taking either quinine or quinidine could be demonstrated readily with the51Cr platelet lysis test and could also be detected by other methods e
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