Linkage Disequilibrium Measures for Fine-Scale Mapping: A Comparison
作者:
Sun-Wei Guo,
期刊:
Human Heredity
(Karger Available online 1997)
卷期:
Volume 47,
issue 6
页码: 301-314
ISSN:0001-5652
年代: 1997
DOI:10.1159/000154430
出版商: S. Karger AG
关键词: Fine-scale mapping;Linkage disequilibrium;Linkage disequilibrium measures;Mutation;Population genetics
数据来源: Karger
摘要:
We investigate properties of simple linkage disequilibrium mapping for five measures in the presence of mutation at the marker and/or the disease locus and of initial incomplete linkage disequilibrium. In contrast to the stimulation approach that Devlin and Risch used, we calculate the expected values of various linkage disequilibrium measures under different assumptions based on a framework for linkage disequilibrium mapping. These expected values clearly demonstrate the expected performance of these measures. We find that the impact of marker mutation on their performance depends on the magnitude of the mutation relative to the proximity of the marker (i.e. recombination fraction between the marker and the disease locus). In the presence of recurrent mutation at the marker and/or disease locus, the performance of all measures, including the robust one, depends on the marker allele frequency. The initial incomplete linkage disequilibrium could render all measures useless. These expected values also show clearly why in Devlin and Risch’s simulation some measures performed very badly under certain circumstance
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