Acidic Fibroblast Growth Factor Accelerates Dermal Wound Healing
作者:
MellinTheodore N.,
MennieRobert J.,
CashenDoreen E.,
RonanJohn J.,
CapparellaJoanna,
JamesMary Lou,
DisalvoJerry,
FrankJohn,
LinemeyerDavid,
GimenezGuillermo,
ThomasKenneth A.,
期刊:
Growth Factors
(Taylor Available online 1992)
卷期:
Volume 7,
issue 1
页码: 1-14
ISSN:0897-7194
年代: 1992
DOI:10.3109/08977199209023933
出版商: Taylor&Francis
关键词: wound closure;wound strength;granulation tissue;angiogenesis;endothelial cell;BS-I lectin
数据来源: Taylor
摘要:
AbstractAcidic fibroblast growth factor (aFGF) is a potent mitogenin vitrofor many cells of ectodermal and mesodermal embryonic origin including skin-derived epidermal keratinocytes, dermal fibroblasts and vascular endothelial cells. Based on the mitogenic activity for these skin-derived cells, we tested the ability of topically applied aFGF to promote healing of full-thickness dermal wounds in healthy rodents. Low doses of aFGF can produce almost a two-fold maximum acceleration in the rate of closure of full-thickness dermal punch biopsy wounds in young healthy mice and rats. The mitogen also produces a 3 to 4 day acceleration in the time to complete closure in rats. Quantitative histomorphometric analysis of wound tissue shows that aFGF induces a marked stimulation of angiogenesis, granulation tissue formation and the growth of new epithelium, but does not promote dermal contraction. Application of aFGF to linear incisions in rat skin produces a transient increase in wound tensile strength accompanied by enhanced cellularity and deposition of collagen. Therefore, aFGF functions as a pharmacological agent that can accelerate dermal wound healing in rodents and could act therapeutically to promote dermal tissue repair in humans.
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