Effects of n‐3 and n‐6 Fatty Acid‐Enriched Diets on Plasma Lipoproteins and Apolipoproteins in Heterozygous Familial Hypercholesterolemia
作者:
Karen Friday,
R. Failor,
Marian Childs,
Edwin Bierman,
期刊:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
(OVID Available online 1991)
卷期:
Volume 11,
issue 1
页码: 47-54
ISSN:1049-8834
年代: 1991
出版商: OVID
关键词: familial hypercholesterolemia;lipoproteins;fish oil;unsaturated dietary fats;unsaturated fatty acids
数据来源: OVID
摘要:
Polyunsaturated fatty acids in vegetable (n-6) and marine (n-3) oils have been shown to reduce cholesterol levels in normolipidemic individuals. However, there is relatively little information available on the lipoprotein responses to dietary n-6 and n-3 fatty acids in individuals with genetic forms of hyperlipidemia at risk for premature cardiovascular disease. We studied five subjects with heterozygous familial hypercholesterolemia (FH), as well as five normal controls, on three rigidly controlled diets differing primarily in their fatty acid composition. FH subjects reduced their total plasma cholesterol by 34% during the n-3 diet and by 26% with the n-6 diet (both p<0.001) when compared with values while on a butter diet In addition, low density lipoprotein (LDL) cholesterol fell 31% and 29% (bothp<0.001), and apolipoprotein B (apo B) levels dropped 28% and 27% (both p<0.01) during the n-3 and n-6 diets, respectively. A significant reduction of total and LDL cholesterol as well as of apo B was also noted in normal controls during n-3 and n-6 diets. Total plasma triglyceride and high density lipoprotein cholesterol fell significantly during n-3 diets in normal and FH subjects. Thus, FH and normal subjects respond in a similar fashion to diets low in saturated fatty acids and rich in n-3 and n-6, with decreased LDL cholesterol and apo B concentrations.
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