Systemic HistiocytosisAn Unusual Cause of Perianal Disease in a Child
作者:
S.,
Moroz M.,
Schroeder C.,
Trevenen H.,
期刊:
Journal of Pediatric Gastroenterology and Nutrition
(OVID Available online 1984)
卷期:
Volume 3,
issue 2
页码: 309-311
ISSN:0277-2116
年代: 1984
出版商: OVID
关键词: Perianal disease;Systemic histiocytosis;Gingival disease;Alveolar bone erosion
数据来源: OVID
摘要:
A male child first presented with chronic perianal skin disease at 33 months of age and later developed gingival disease and loose teeth associated with alveolar bone erosion. Biopsy of gingival and perianal lesions showed histiocytic proliferation. Following therapy with vinblastine, prednisone, methotrexate, and cyclophosphamide, the lesions healed but disease recurred in the mastoid and was successfully treated with vinblastine alone. Although the perianal area is an unusual site of skin involvement in systemic histiocytosis, this disorder should be considered in any child with chronic unexplained perianal disease, and biopsy of these lesions should be obtained.
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