Modeling Glucose Distribution in the Cornea
作者:
McCareyBernard E.,
SchmidtFredrick H.,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 11
页码: 1025-1039
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008997577
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The central cornea obtains its glucose by diffusion through the cornea from the aqueous humor to the epithelium. The diffusion of glucose in the cornea is analogous to the flow of current in an electrical resistance network. The cellular consumption of glucose can be compared to shunting a portion of the charge to electrical ground. An electrical analog model of the cornea was developed to predict the availability of glucose to the epithelium and the distribution of glucose in the stroma. The glucose constant concentration lines in the normal stroma are parallel to the corneal surface and have decreasing values from 880 to 580μg/ml. The effects on epithelial glucose concentration by implanting an intracorneal lens (ICL) of varying diameter, depth, permeability and thickness can be modeled. Glucose permeability through the intracorneal lens has the most significant effect on glucose availability. The ICL profile i.e. power, can also be an important fact in determining glucose availability. A minus power design requires a thin central lens zone with a thick peripheral zone. The design results in relatively more glucose flux through the optical zone of the lens and thus improves central epithelial glucose availability.
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